2023
Adams, F.; Zimmermann, C. M.; Luciani, P.; Merkel, O. M., Chapter 9 - Microfluidics for nanopharmaceutical and medical applications. In Microfluidics for Cellular Applications, Perozziello, G.; Krühne, U.; Luciani, P., Eds. Elsevier: 2023; pp 343-408. https://doi.org/10.1016/B978-0-12-822482-3.00010-5
Jin, Y.; Adams, F.; Möller, J.; Isert, L.; Zimmermann, C. M.; Keul, D.; Merkel, O. M., Synthesis and Application of Low Molecular Weight PEI-Based Copolymers for siRNA Delivery with Smart Polymer Blends. Macromol. Biosci. 2023, 23 (2), e2200409. https://doi.org/10.1002/mabi.202200409
Gabold, B.; Adams, F.; Brameyer, S.; Jung, K.; Ried, C. L.; Merdan, T.; Merkel, O. M., Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins. Drug Deliv. Transl. Res. 2023, 13 (3), 822-838. https://doi.org/10.1007/s13346-022-01245-z
2022 - 2020
Adams, F.; Merkel, O. M.,Microfluidics for Nanoencapsulation of Nucleic Acids Using Polymeric Carriers, Material Matters, 2022, 17.2. https://www.sigmaaldrich.com/DE/de/technical-documents/technical-article/materials-science-and-engineering/drug-delivery/microfluidics-nanoencapsulation-nucleic-acids-polymeric-carriers
Merkel, O. M.; Adams, F.; Zimmermann, C. M.; Baldassi, D, Process for synthesizing poly(spermine acrylamide) and/or poly(spermine acrylamide-co-N-alkylacrylamide) and their application. European Patent Application No. EP 22 162 499.2. Application Date: March 16th, 2022.
Adams, F.; Rieger, B., Process for polymerizing beta-butyrolactone, U.S. Patent 11 459 423, Oct. 04, 2022.
Hornberger, L.-S.; Adams, F., Photocatalytic CO2 Conversion Using Metal-Containing Coordination Polymers and Networks: Recent Developments in Material Design and Mechanistic Details. Polymers, 2022,14 (14), 2778. https://doi.org/10.3390/polym14142778
Al-Shok, L.; Haddleton, D. M.; Adams, F., Progress in Catalytic Ring-Opening Polymerization of Biobased Lactones. In: Advances in Polymer Science. Springer Berlin Heidelberg: Berlin, Heidelberg, 2022; pp 1-71. https://doi.org/10.1007/12_2021_111
Oliveira-Filho, E. R.; de Macedo, M. A.; Lemos, A. C. C.; Adams, F.; Merkel, O. M.; Taciro, M. K.; Gomez, J. G. C.; Silva, L. F., Engineering Burkholderia sacchari to enhance poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] production from xylose and hexanoate. Int. J. Biol. Macromol., 2022, 213, 902-914. https://doi.org/10.1016/j.ijbiomac.2022.06.024.
Kränzlein, M.; Pehl, T. M.; Adams, F.; Rieger, B., Uniting Group-Transfer and Ring-Opening Polymerization─Block Copolymers from Functional Michael-Type Monomers and Lactones. Macromolecules 2021, 54 (23), 10860-10869. 10.1021/acs.macromol.1c01692.
Pehl, T. M.; Adams, F.; Kränzlein, M.; Rieger, B., Expanding the Scope of Organic Radical Polymers to Polyvinylphosphonates Synthesized via Rare-Earth Metal-Mediated Group-Transfer Polymerization. Macromolecules 2021, 54 (9), 4089-4100.10.1021/acs.macromol.1c00217.
Keil, T. W.; Zimmermann, C.; Baldassi, D.; Adams, F.; Friess, W.; Mehta, A.; Merkel, O. M., Impact of crystalline and amorphous matrices on successful spray drying of siRNA polyplexes for inhalation of nano-in-microparticles. Adv. Ther. 2021, 4 (6). 10.1002/adtp.202100073.
Isert, L.; Mehta, A.; Adams, F.; Merkel, O. M., Tracking siRNA–Nanocarrier Assembly and Disassembly Using FRET. In: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery. Springer US: New York, NY, 2021; pp 383-396.
Hartl, N.; Adams, F.; Merkel, O. M., From adsorption to covalent bonding: Apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood-brain barrier. Adv. Ther. 2021, 4 (1), 2000092. 10.1002/adtp.202000092.
Pehl, T. M.; Kränzlein, M.; Adams, F.; Schaffer, A.; Rieger, B., C–H Bond Activation of Silyl-Substituted Pyridines with Bis (Phenolate) Yttrium Catalysts as a Facile Tool towards Hydroxyl-Terminated Michael-Type Polymers. Catalysts 2020, 10 (4), 448. 10.3390/catal10040448.
Adams, F.; Pehl, T. M.; Kränzlein, M.; Kernbichl, S. A.; Kang, J.-J.; Papadakis, C. M.; Rieger, B., (Co)polymerization of (−)-menthide and β-butyrolactone with yttrium-bis(phenolates): tuning material properties of sustainable polyesters. Polym. Chem. 2020, 11 (27), 4426-4437. 10.1039/D0PY00379D.
2019 - 2015
Hartl, N.; Adams, F.; Costabile, G.; Isert, L.; Döblinger, M.; Xiao, X.; Liu, R.; Merkel, M. O., The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells. Nanomaterials 2019, 9 (7). 910.3390/nano9070986.
Adams, F.; Pahl, P.; Rieger, B., Metal‐catalyzed group‐transfer polymerization: a versatile tool for tailor‐made functional (Co) polymers. Chem. Eur. J. 2018, 24 (3), 509-518. 10.1002/chem.201703965.
Adams, F.; Pschenitza, M.; Rieger, B., Yttrium‐Catalyzed Synthesis of Bipyridine‐Functionalized AB‐Block Copolymers: Micellar Support for Photocatalytic Active Rhenium‐Complexes. ChemCatChem 2018, 10 (19), 4309-4316. 10.1002/cctc.201801009.
Adams, F.; Machat, M. R.; Altenbuchner, P. T.; Ehrmaier, J.; Pöthig, A.; Karsili, T. N.; Rieger, B., Toolbox of nonmetallocene lanthanides: multifunctional catalysts in group-transfer polymerization. Inorg. Chem. 2017, 56 (16), 9754-9764. 10.1021/acs.inorgchem.7b01261.
Kernbichl, S.; Reiter, M.; Adams, F.; Vagin, S.; Rieger, B., CO2-controlled one-pot synthesis of AB, ABA block, and statistical terpolymers from β-butyrolactone, epoxides, and CO2. J. Am. Chem. Soc. 2017, 139 (20), 6787-6790. 10.1021/jacs.7b01295.
Vagin, S. I.; Kronast, A.; Altenbuchner, P. T.; Adams, F.; Sinkel, C.; Deglmann, P.; Loos, R.; Schuffenhauer, T.; Sommer, B.; Bruck, T.; Rieger, B., Enzymatic degradation of synthetic poly(3-hydroxybutyrates) as a tool for combinatorial microstructure determination. Polym. Degrad. Stab. 2017, 143, 176-185. 10.1016/j.polymdegradstab.2017.07.007.
Adams, F.; Altenbuchner, P.; Werz, P.; Rieger, B., Multiresponsive micellar block copolymers from 2-vinylpyridine and dialkylvinylphosphonates with a tunable lower critical solution temperature. RSC Adv. 2016, 6 (82), 78750-78754. 10.1039/c6ra17160e.
Altenbuchner, P. T.; Werz, P. D.; Schöppner, P.; Adams, F.; Kronast, A.; Schwarzenböck, C.; Pöthig, A.; Jandl, C.; Haslbeck, M.; Rieger, B., Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells. Chem. Eur. J. 2016, 22 (41), 14576-14584. 10.1002/chem.201601822.
Adams, F., Gruppentransferpolymerisation von Michael-Monomeren: Untersuchung von C1-symmetrischen Komplexen. Springer Best Masters, Springer-Verlag, 2016. ISBN: 3658135743.
Altenbuchner, P.; Adams, F.; Kronast, A.; Herdtweck, E.; Pöthig, A.; Rieger, B., Stereospecific catalytic precision polymerization of 2-vinylpyridine via rare earth metal-mediated group transfer polymerization with 2-methoxyethylamino-bis (phenolate)-yttrium complexes. Polym. Chem. 2015, 6 (38), 6796-6801. 10.1039/c5py01146a.
Selected Publications
Polyvinylphosphonates as Organic Radical Polymers
The synthesis of organic radical polymers (ORPs) is expanded to the field of rare-earth metal-mediated group-transfer polymerization (REM-GTP).
Photo: (c) American Chemical Society, Dr. Johannes Richers
Metal-Catalyzed Group-Transfer Polymerization
The symbiosis of group-transfer polymerization and functional materials: Metal-catalyzed group-transfer polymerization has made major contributions to the precise synthesis of macromolecules to give access to a plethora of homo- and copolymers based on polar vinyl monomers. Thereby, GTP has established its potential to design functional and smart polymers. This concept article illustrates the significant progress in metal-catalyzed GTP focusing on functional (co)polymers including various polymeric architectures.
(Co)polymerization of (−)-menthide and β-butyrolactone with yttrium-bis(phenolates)
Yttrium-bis(phenolate) complexes were investigated in ring-opening polymerization of racemic β-butyrolactone (rac-BBL) and (−)-menthide. In addition, AB and BAB copolymers from poly((−)-menthide) (PM, block A) and poly(3-hydroxybutyrate) (PHB, block B) were synthesized via sequential addition.