Publications

Adams, F.*;  Zimmermann, C. M.;  Baldassi, D.;  Pehl, T. M.;  Weingarten, P.;  Kachel, I.;  Kranzlein, M.;  Jurgens, D. C.;  Braubach, P.;  Alexopoulos, I.;  Wygrecka, M.; Merkel, O. M.*, Pulmonary siRNA Delivery with Sophisticated Amphiphilic Poly(Spermine Acrylamides) for the Treatment of Lung Fibrosis. Small 2023, e2308775. https://doi.org/10.1002/smll.202308775

Hornberger, L.-S.;  Weingarten, P.;  Lange, P. L.;  Schleid, T.; Adams, F.*, Connecting 16- with 4-Membered Rings: Ring-Opening Polymerization of Bio-Based ω-Pentadecalactone with Amino-Alkoxy-Bis(phenolate) Yttrium Initiators and Copolymerization with β-Butyrolactone. Eur. Polym. J. 2023, 199, 112449. https://doi.org/10.1016/j.eurpolymj.2023.112449 

Hamedani, Y. P.; Çakırefe, S.; Fietz, A.; Hurst, J.; Schnichels, S.; Adams, F.*, The Effect of MPEGA/EHA Ratio and Copolymer Composition on the Solution Behaviour of Amphiphilic, Comb-Shape Copolymers Synthesized via Cu(0)-mediated SET-LRP for Potential Drug Delivery Applications. Macromol. Chem. Phys. 2023, 224, 2300226.https://doi.org/10.1002/macp.202300226 (Special Issue: 80 Years of MCP: The Next Generation of Polymer Researchers) 

Adams, F.;  Zimmermann, C. M.;  Luciani, P.; Merkel, O. M.*, Chapter 9  - Microfluidics for nanopharmaceutical and medical applications. In Microfluidics for Cellular Applications, Perozziello, G.;  Krühne, U.; Luciani, P., Eds. Elsevier: 2023; pp 343-408. https://doi.org/10.1016/B978-0-12-822482-3.00010-5

Jin, Y.;  Adams, F.;  Möller, J.;  Isert, L.;  Zimmermann, C. M.;  Keul, D.; Merkel, O. M.*, Synthesis and Application of Low Molecular Weight PEI-Based Copolymers for siRNA Delivery with Smart Polymer Blends. Macromol. Biosci. 2023, 23 (2), e2200409. https://doi.org/10.1002/mabi.202200409

Jin, Y.; Adams, F.; Nguyen, A.; Sturm, S.; Carneiro, S. P.; Müller-Caspary, K.; Merkel, O.M.*, Synthesis and application of spermine-based amphiphilic poly(β-amino ester)s for siRNA delivery. Nanoscale Adv. 2023. https://doi.org/10.1039/D3NA00272A

Jin, Y.;  Adams, F.;  Isert, L.;  Baldassi, D.; Merkel, O. M.*, Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer. Mol. Pharm. 2023. https://doi.org/10.1021/acs.molpharmaceut.3c00206

Gabold, B.;  Adams, F.;  Brameyer, S.;  Jung, K.;  Ried, C. L.;  Merdan, T.; Merkel, O. M.*, Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins. Drug Deliv. Transl. Res. 2023, 13 (3), 822-838. https://doi.org/10.1007/s13346-022-01245-z

Moinet, E. C.;  Tardif, O.;  Hornberger, L.-S.;  Adams, F.;  Maichle-Mössmer, C.; Anwander, R.*, Discrete Trivalent Lanthanide Isobutylaluminates in Isoprene Polymerization: Elucidation of Cationized Active Species. ACS Catal. 2023, 12826-12834. https://doi.org/10.1021/acscatal.3c02247

Hartl, N.;  Gabold, B.;  Adams, F.;  Uhl, P.;  Oerter, S.;  Gatzner, S.;  Metzger, M.;  Konig, A. C.;  Hauck, S. M.;  Appelt-Menzel, A.;  Mier, W.;  Fricker, G.; Merkel, O. M.*, Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models. J. Control. Release 2023. https://doi.org/10.1016/j.jconrel.2023.07.019

Adams, F.*;  Merkel, O. M.,Microfluidics for Nanoencapsulation of Nucleic Acids Using Polymeric Carriers, Material Matters, 2022, 17.2. https://www.sigmaaldrich.com/DE/de/technical-documents/technical-article/materials-science-and-engineering/drug-delivery/microfluidics-nanoencapsulation-nucleic-acids-polymeric-carriers

Merkel, O. M.; Adams, F.; Zimmermann, C. M.; Baldassi, D, Process for synthesizing poly(spermine acrylamide) and/or poly(spermine acrylamide-co-N-alkylacrylamide) and their application. European Patent Application No. EP 22 162 499.2. Application Date: March 16th, 2022.

Adams, F.; Rieger, B., Process for polymerizing beta-butyrolactone, U.S. Patent 11 459 423, Oct. 04, 2022.

Hornberger, L.-S.; Adams, F.*, Photocatalytic CO₂ Conversion Using Metal-Containing Coordination Polymers and Networks: Recent Developments in Material Design and Mechanistic Details. Polymers, 2022,14 (14), 2778. https://doi.org/10.3390/polym14142778

Oliveira-Filho, E. R.;  de Macedo, M. A.;  Lemos, A. C. C.;  Adams, F.;  Merkel, O. M.;  Taciro, M. K.;  Gomez, J. G. C.; Silva, L. F.*, Engineering Burkholderia sacchari to enhance poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] production from xylose and hexanoate. Int. J. Biol. Macromol., 2022, 213, 902-914. https://doi.org/10.1016/j.ijbiomac.2022.06.024.  

Kränzlein, M.;  Pehl, T. M.;  Adams, F.*; Rieger, B.*, Uniting Group-Transfer and Ring-Opening Polymerization─Block Copolymers from Functional Michael-Type Monomers and Lactones. Macromolecules 2021, 54 (23), 10860-10869. 10.1021/acs.macromol.1c01692.

Pehl, T. M.;  Adams, F.;  Kränzlein, M.; Rieger, B.*, Expanding the Scope of Organic Radical Polymers to Polyvinylphosphonates Synthesized via Rare-Earth Metal-Mediated Group-Transfer Polymerization. Macromolecules 2021, 54 (9), 4089-4100.10.1021/acs.macromol.1c00217.

Keil, T. W.;  Zimmermann, C.;  Baldassi, D.;  Adams, F.;  Friess, W.;  Mehta, A.; Merkel, O. M.*, Impact of crystalline and amorphous matrices on successful spray drying of siRNA polyplexes for inhalation of nano-in-microparticles. Adv. Ther. 2021, 4 (6). 10.1002/adtp.202100073.

Isert, L.;  Mehta, A.;  Adams, F.; Merkel, O. M.*, Tracking siRNA–Nanocarrier Assembly and Disassembly Using FRET. In: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery. Springer US: New York, NY, 2021; pp 383-396.

Hartl, N.;  Adams, F.; Merkel, O. M.*, From adsorption to covalent bonding: Apolipoprotein E functionalization of polymeric nanoparticles for drug delivery across the blood-brain barrier. Adv. Ther. 2021, 4 (1), 2000092. 10.1002/adtp.202000092.

Pehl, T. M.;  Kränzlein, M.;  Adams, F.;  Schaffer, A.; Rieger, B.*, C–H Bond Activation of Silyl-Substituted Pyridines with Bis (Phenolate) Yttrium Catalysts as a Facile Tool towards Hydroxyl-Terminated Michael-Type Polymers. Catalysts 2020, 10 (4), 448. 10.3390/catal10040448.

Adams, F.;  Pehl, T. M.;  Kränzlein, M.;  Kernbichl, S. A.;  Kang, J.-J.;  Papadakis, C. M.; Rieger, B.*, (Co)polymerization of (−)-menthide and β-butyrolactone with yttrium-bis(phenolates): tuning material properties of sustainable polyesters. Polym. Chem. 2020, 11 (27), 4426-4437. 10.1039/D0PY00379D.

Hartl, N.;  Adams, F.;  Costabile, G.;  Isert, L.;  Döblinger, M.;  Xiao, X.;  Liu, R.; Merkel, M. O.*, The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells. Nanomaterials 2019, 9 (7).  910.3390/nano9070986.

Adams, F.;  Pahl, P.; Rieger, B.*, Metal‐catalyzed group‐transfer polymerization: a versatile tool for tailor‐made functional (Co) polymers. Chem. Eur. J. 2018, 24 (3), 509-518. 10.1002/chem.201703965.

Adams, F.;  Pschenitza, M.; Rieger, B.*, Yttrium‐Catalyzed Synthesis of Bipyridine‐Functionalized AB‐Block Copolymers: Micellar Support for Photocatalytic Active Rhenium‐Complexes. ChemCatChem 2018, 10 (19), 4309-4316.  10.1002/cctc.201801009.

Adams, F.;  Machat, M. R.;  Altenbuchner, P. T.;  Ehrmaier, J.;  Pöthig, A.;  Karsili, T. N.; Rieger, B.*, Toolbox of nonmetallocene lanthanides: multifunctional catalysts in group-transfer polymerization. Inorg. Chem. 2017, 56 (16), 9754-9764. 10.1021/acs.inorgchem.7b01261. 

Kernbichl, S.;  Reiter, M.;  Adams, F.;  Vagin, S.; Rieger, B.*, CO₂-controlled one-pot synthesis of AB, ABA block, and statistical terpolymers from β-butyrolactone, epoxides, and CO₂. J. Am. Chem. Soc. 2017, 139 (20), 6787-6790. 10.1021/jacs.7b01295.

Vagin, S. I.;  Kronast, A.;  Altenbuchner, P. T.;  Adams, F.;  Sinkel, C.;  Deglmann, P.;  Loos, R.;  Schuffenhauer, T.;  Sommer, B.;  Bruck, T.; Rieger, B.*, Enzymatic degradation of synthetic poly(3-hydroxybutyrates) as a tool for combinatorial microstructure determination. Polym. Degrad. Stab. 2017, 143, 176-185. 10.1016/j.polymdegradstab.2017.07.007.

Adams, F.;  Altenbuchner, P.;  Werz, P.; Rieger, B.*, Multiresponsive micellar block copolymers from 2-vinylpyridine and dialkylvinylphosphonates with a tunable lower critical solution temperature. RSC Adv. 2016, 6 (82), 78750-78754. 10.1039/c6ra17160e.

Altenbuchner, P. T.;  Werz, P. D.;  Schöppner, P.;  Adams, F.;  Kronast, A.;  Schwarzenböck, C.;  Pöthig, A.;  Jandl, C.;  Haslbeck, M.; Rieger, B.*, Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells. Chem. Eur. J. 2016, 22 (41), 14576-14584. 10.1002/chem.201601822.

Adams, F., Gruppentransferpolymerisation von Michael-Monomeren: Untersuchung von C1-symmetrischen Komplexen. Springer Best Masters, Springer-Verlag, 2016. ISBN: 3658135743.

Altenbuchner, P.;  Adams, F.;  Kronast, A.;  Herdtweck, E.;  Pöthig, A.; Rieger, B.*, Stereospecific catalytic precision polymerization of 2-vinylpyridine via rare earth metal-mediated group transfer polymerization with 2-methoxyethylamino-bis (phenolate)-yttrium complexes. Polym. Chem. 2015, 6 (38), 6796-6801. 10.1039/c5py01146a.